Journal of clinical investigation, a recent research by the the, published a new study on French scientists, who found that oxidative stress promotes the development of non alcoholic fatty liver disease (NAFLD), which is a step in promoting the development of liver cancer. The results may be important for the prevention of liver cancer induced by non alcoholic fatty liver disease.
It is a very big change in the genome that may occur in the liver, and physiological processes in the development of liver and the whole life may occur. But G raldine, Gentric and other researchers found that in the non alcoholic fatty liver, it will also occur chromosome of the chromosome. Non alcoholic fatty liver disease is relatively common in the world within the scope of the liver metabolic disorder, and studies have shown that non alcohol fatty liver may be lead to a risk factor for hepatocellular carcinoma (HCC).
The researchers found that fatty liver entities in the model of a non alcoholic fatty liver disease showed a change in the process of the process of the development of the fatty liver, including the emergence of a number of highly - and highly - oriented, single - nuclear cells, which are very rare in normal liver. The liver of patients with non alcoholic fatty liver disease was found to have a lot of NASH cells in the liver tissues of normal liver tissues. Further study of the mechanism, the researchers confirmed that NAFLD liver cells and can not effectively through the cell cycle in the S/G2 phase, mainly because the G2/M test point to prevent the activation of the cyclinB1/CDK1 complex, leading to cell cycle can not be normal, appear in the. The researchers also found that oxidative stress can promote the emergence of the liver of the liver cells, the antioxidant treatment of NAFLD liver cells can restore the normal cell cycle, so that the cells return to the physiological state of the.
In summary, this article found that the pathological changes of the liver cells in NAFLD, which is caused by the cell cycle suspension during the S/G2 phase, also confirmed that oxidative stress can promote the pathological changes of NAFLD. The results of this study have important implications for the prevention of liver cancer induced by non-alcoholic fatty liver disease.